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Authors 
Sanudo-Pena MC. Walker JM.

Institution 
Department of Psychology, Brown University, Providence, Rhode Island 02912, USA. Clara@Poppy.Psych.Brown.Edu

Title 
Effects of intrapallidal cannabinoids on rotational behavior in rats: interactions with the dopaminergic system.

Source 
Synapse. 28(1):27-32, 1998 Jan.

Abstract 
The effect of unilateral intrapallidal cannabinoid receptor stimulation on rotational behavior in rats was explored. The potent cannabinoid agonist CP55,940 (5 microg/0.5 microl) induced ipsilateral turning when microinjected unilaterally into the globus pallidus. The D2 dopamine agonist quinpirole reversed this ipsilateral rotation but failed to affect motor behavior on its own. Finally, the D1 dopamine agonist SKF 82958 inhibited movement when administered into the globus pallidus, and this effect was not additive with CP55,940.

sanudo-pena-01.pdf
 file size: 85.17KB (87211 bytes)